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33. The Study of Mechanism By Which The Telomerase Template Phosphorothioate Antisense Oligonucleoti
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靶向药物为急性髓系白血病（AML）治疗带来巨大进步。随着研究的深入，靶向药物治疗耐药、联合治疗不良反应叠加、缺乏有效靶点等问题亦......
The tumor suppressor p53 plays an important role in the inhibition of cancer progression,particularly in response to che......
Botulinum neurotoxins serotype A(BoNT/A)is the deadliest toxins known to humans and the“Category A”agent for bioterror......
Hybeanones A and B (1 and 2),two highly oxygenated and rearranged polycyclic polyprenylated acylphloroglucinols (PPAPs),......
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目的近年来已认识到,在糖尿病心肌病（diabetic cardiomyopathy DCM）发生过程中心肌成纤维细胞（cardiac fibroblasts CFs）在心肌重构中......
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Food wastes are the main part of the organic wastes in many countries.Due to the diverse sources of food waste produced ......
The boundary conditions leading to pitting in pipelines in the water/hydrocarbon (HC) interface region of the bottom-of-......
p21-activated kinases(PAKs)are a family of serine/threonine kinases that act downstream of Rho GTPases,Rac and Cdc42....
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p38 mitogen-activated protein kinases (p38 MAPK,p38) consist of 4 subunits: p38α,p38β,p38γ and p38δ.They play a well......
Protein Arginine Phosphatase YwlE Assay Based on colorimetric substrate p-nitrophenyl phosphate(pNPP
Protein arginine phosphorylation represents a novel post-translation modification that alters protein function.Protein a......
Discovery of potent signal transducer and activator of transcription 3(STAT3)signaling pathway inhib
Protein-protein interactions(PPIs)are critical targets for pharmacological intervention.Constitutive activation of signa......
Protein kinase CK2 is a multifunctional serine/threonine kinase that involved in a broad range of physiological events,a......
The aim of the present study was to discover human mitotic kinesin protein Eg5 inhibitors.The human Eg5 eDNA was obtaine......
Cathepsin K(CTSK),a member of lysosomal cysteine proteases,has been implicated in the process of bone resorption [1].Inh......
Synthesis and biological evaluation of novel HIV-1 Protease inhibitors using tertiary amine as P2-li
Aims: The tri-THF protease inhibitor,GRL-0519,with excellent antiviral activity on drug resistant virus,showed the abili......
Cyclin-dependent kinases(CDKs)are pivotal kinases in eukaryocyte.As an important member of the CDK family,CDK9 plays a k......
OBJECTIVE To screen potential protein tyrosine kinases (PTKs) inhibitors.A high-throughput screening model based on the ......
The PI3K/Akt/mTOR(PAM)signaling pathway plays a key regulatory function in cell survival,proliferation,migration,radioth......
Aspergillus fumigatus is a filamentous airborne saprophytic fungus and regarded as one of the most pernicious pathogens ......
The kidney plays an essential role for the bodys glucose homeostasis,and the sodium-glucose co-transporter 2 (SGLT2) off......
Small molecule inhibitor targeting the DNA-binding domain of STAT3 suppresses tumor growth and STAT3
Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in malignant tumors and plays imp......
AIM To compare the inhibitory effects of mangiferin and mangiferin sodium salt on influenza neuraminidase.METHODS Neuram......
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Design,synthesis and biological activities of novel inhibitors against pyruvate dehydrogenase E1 fro
The increasing accidence of cyanobacterial blooms was witnessed in decades around the world.Pyruvate dehydrogenase catal......
β-Lactam antibiotics are widely used in the treatment of bacterial infections.However,The overuse of antibiotics leads ......
Separation and determination of active ingredients in Hedyotis diffusa Willd by capillary electropho
A high-performance capillary electrophoresis (CE) with diode array detector (DAD) method was developed for the determina......
IE-OP06:Synthesis, characterization and DFT studies of Bis4-methylpiperidiniummethyl-urea as corrosi
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Amyloid fibril assembly is associated with many human disorders,[1] and to approach an inhibitor of amyloid formation th......
Multi-targeting anticancer drug that a molecule termed combi-molecule (C-molecule) with binary epidermal growth factor r......
Discovery of Novel JAK2 Inhibitors via Integration of Pharmacophore Mapping and Molecular Docking in
The JAK2 kinase has been proved to be critically involved in receptor signaling,and emerged as a leading therapeutic tar......
The Bcl-2 family consists of several proteins that share Bcl-2 homology(BH) domain and control apoptosis by governing mi......
Acetyl-CoA carboxylase(ACCase)catalyzes the conversion of acetyl-CoA to malonyl-CoA which is the first step of the synth......
Synthesis,biological evaluation and molecular docking studies of novel l-(4,5-dihydro-lH-pyrazol-1-y
A series of novel compounds(6a-6v)containing l-methylindol and 31-(4,5-dihydro-lH-pyraxol-1-yl)ethanone skeleton were de......
Background: Tyrosinase plays a key role in the formation of skin melanin.The excessive accumulation of skin melanin will......
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Statins have been shown to be effective in reducing cardiovascular events.Their magnitude of benefits has been proportio......
Sodium-glucose cotransporter 2(SGLT2)inhibitors have gained momentum as the latest class of antidiabetic agents for impr......
Chronic myeloid leukemia (CML) associated with pregnancy is a very rare situation (less than one case per 100</span></sp......
Development of Novel Benzimidazole Derivates as Potent and Selective Akt Kinase Inhibitors Using &am
The serine/threonine Akt kinase signaling pathway plays an essential role not only in tumorigenesis but also in the pote......
The coronavirus disease 2019(COVID-19)caused by severe acute respiratory disease respiratory syndrome coronavirus-2 has ......
Euglycemic diabetic ketoacidosis(DKA)is an acute life-threatening metabolic emergency characterized by ketoacidosis and ......
Mechanisms of acquired resistance of BRCA1/2-driven tumors to platinum compounds and PARP inhibitors
Molecular pathogenesis of tumors arising in BRCA1/2 germ-line mutation carriers usually includes somatic inactivation of......
Paradoxical relationship between proton pump inhibitors and COVID-19: A systematic review and meta-a
BACKGROUND The proton pump inhibitors(PPIs),used to reduce gastric acid secretion,represent one of the most widely used ......
